Experimental transmission of Mayaro virus by Aedes aegypti.

نویسندگان

  • Kanya C Long
  • Sarah A Ziegler
  • Saravanan Thangamani
  • Nicole L Hausser
  • Tadeusz J Kochel
  • Stephen Higgs
  • Robert B Tesh
چکیده

Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log(10) and 7.3 log(10) plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log(10) PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.

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عنوان ژورنال:
  • The American journal of tropical medicine and hygiene

دوره 85 4  شماره 

صفحات  -

تاریخ انتشار 2011